Pathologic Analysis of Pulmonary Interstitial Fibrosis

Primary Interstitial Pulmonary Fibrosis: Clinico-pathologic Aspects of the Disease.

Familial Interstitial Pulmonary Fibrosis.

In 1944 Hamman and Rich first described a disease that caused an acute diffuse interstitial fibrosis of the lungs, and which resulted in the death of four patients within six months of the onset of symptoms. Since then countless further cases have been reported in the literature, and our knowledge of the subject has advanced. It is recognized that the interstitial fibrotic process may be locali...

Interstitial pulmonary fibrosis.

The study of animal models of IPF has demonstrated that there is a stereotyped response of the respiratory airspace walls to a wide variety of injuries. Inflammatory and immune effector cells play a major and complex role in the fibrosing process. They may contribute to the injury of the lung beyond the original insult. These cells secrete substances that play an important role in determining c...

Idiopathic interstitial pulmonary fibrosis. Contribution of bronchoalveolar lavage analysis.

T interstitial lung diseases are a heterogeneous group o f diseases that affect the supporting structure o f the airexchange units , especia l ly t h e peria lveolar t issue and alveolar walls. T h e initial host response to t h e disease process is inflammation in the alveolar walls and airspaces, causing an acute phase o f mural and luminal alveolitis, followed by the c o n s e q u e n c e s ...

Automated Analysis of Crackles in Patients with Interstitial Pulmonary Fibrosis

Background. The crackles in patients with interstitial pulmonary fibrosis (IPF) can be difficult to distinguish from those heard in patients with congestive heart failure (CHF) and pneumonia (PN). Misinterpretation of these crackles can lead to inappropriate therapy. The purpose of this study was to determine whether the crackles in patients with IPF differ from those in patients with CHF and P...